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The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behaviour have gained more importance in recent decades. During the recent years there has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive biological activities. Among of these compounds having 1,3,4 - thiadiazole nucleus are known to possess anti-inflammatory, analgesic, antimicrobial, antitumor, antifungal, antimycobacterial, anticonvulsant, antidiabetic, antiviral, activities. So far, modification of the thiadiazole ring have proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized thiadiazole possessing important biological activities.
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Author(s): Kratika Shrivastava Suresh Purohit Sarita Singhal
1, 3, 4-Thiadiazole, antibacterial, antitubercular, vasodialatory, antifungal, cytotoxic, antiinflammatory, analgesic, hypolipidemic, anticancer and ulcerogenic activities