alexa Abstract | Studies on Process Parameters for Production of Lovastatin

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Lovastatin is a natural secondary metabolite produced by Aspergillus terreus. Optimization of different process parameters like pH of medium, incubation period and selection of different carbon sources etc. was investigated for maximum production of lovastatin using Aspergillus terreus NCIM 657. The kinetics of lovastatin production was also investigated up to fourteen days of production under batch mode. It was found that a temperature of 28 ?C for incubation, a medium pH 6.5 and an agitation speed of 180rpm for seven days yielded maximum concentration of lovastatin. It was also observed that glucose as a sole carbon source resulted in diminished production of lovastatin as compared to cases where other carbon sources were supplemented in medium along with glucose. Thin layer chromatography, Fourier Transform Infrared spectroscopy analysis confirmed the presence of lovastatin in the sample produced by A. terreus NCIM 657

To read the full article Peer-reviewed Article PDF image

Author(s): Riya Dhar and Vinod Kumar Nigam

Keywords

Aspergillus, Cardiovascular diseases, Cholesterol, HMG CoA reductase, Lovastatin, Thin Layer Chromatography

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords