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Research Paper Open Access
Among calcium channel blockers which are predominantly cardioselective, diltiazem is one which is equieffective with others but has a lower frequency of undesirable effects. The indigeous production of diltiazem is at the elimentary stage and requires 2-aminothiophenol as an important intermediate, the demand of which is being met almost completely by import. The synthesis of this intermediate is attempted by four different routes.
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Author(s): S S Mahajan S J Miranda