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Research Paper Open Access
Pellets of indomethacin were prepared by dropping the suspension of indomethacin, in aqueous sodium alginate solution, into calcium chloride solution. The droplets instantaneously formed gelled spheres by lonotropic gelation. Pellets containing indomethacin were also prepared by solution layering technique and subsequently the drug loaded sugar pellets were coated with ethyl cellulose. Pellets were characterized by drug loading and in-vitro dissolution in phosphate buffer. The effects of formulation factors and process variables on the in-vitro dissolution rate are discussed. Goodness of fit test is used to establish the mechanism of indomethacin release from controlled release systems.