alexa Abstract | Study of the soil isolates for antimicrobial activity

Indian Journal of Pharmaceutical Sciences
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Short Communication Open Access

Abstract

During the process of screening for a potent antimicrobial compound, a new strain was isolated from the soil sample of Thalaikunda village in Ooty, Tamil Nadu. That organism was name as NK 2 . It was found to be antagonistic to both bacterial and fungal test organisms. Production of antibiotic was more in a newly formulated broth. Antibiotic production reached maximum at the end of the 70 h of fermentation by stirred flask culture. The antimicrobial compound was extracted in n -butanol, ethyl acetate and methanol. Antimicrobial compound, which was produced by the soil isolate NK 2 did not showed cytotoxic activity on Vero cell lines.

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Author(s): AR Srividya GS Saritha B Suresh

Keywords

Antimicrobial compounds, fermentation, International Streptomycetes project (ISP), Streptomycetes spp, melanoid formation, milk coagulation, peptonisation

 
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