alexa Abstract | Study of the topical use of Hyptis pectinata extract (sambacaita) in wound healing in rats

Journal of Chemical and Pharmaceutical Research
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Abstract

This study aimed to evaluate the healing action of the ethanol extract of Hyptis pectinata leaves in induced clean wounds in rats. It is a preclinical experimental study approved by the Ethics Committee on the use of animals at the Federal University of Alagoas, under No. 058/2014. After dried, the H. pectinata leaves have undergone the process of extraction by maceration in ethanol to obtain the ethanol extract. We used 27 Wistar rats divided into three groups: experimental group (sambacaitaointment5%), positive control (dexpanthenol ointment 5%) and negative control (nonionic ointment base), all subject to excisional lesions in the middle of the back area. The rats were treated daily for 14 days and the statistical analysis was performed using the Graph Pad Prism System® 6. During the experiments, the animals were observed for the clinical parameters weight, temperature and macroscopic aspects of lesions and their diameter. The mean weight at the postoperative day (POD) was 198.9 ± 1.4 g, reaching 175.2 ± 4.06 g on the 14th POD. It was possible to see an increase in the lesion area on the 3rd POD, followed by a decrease in subsequent days in all groups studied. The value of the body temperature of the animals ranged between 35.2 and 37.5° C. The macroscopic evaluation identified the presence of signs of inflammation, as perilesional blush and exudate in all groups on the 3rd POD and only in PC and NC groups in the 7th POD, not being observed in the following days. During this period, histological specimens were collected for evaluation of the healing process. The ethanol extract did not show better results in reducing the diameter of the wound when compared to the positive control group. There were no significant changes between the groups in histological findings of the wounds. The ethanol extract of H. pectinata showed no healing activity when compared to the positive control group.

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Author(s): Talita Lcio Chaves Vasconcelos Fabiani Tenrio Xavier Povoas Thais Honrio Lins Bernardo Patrcia de Albuquerque Sarmento Regina Clia Sales Santos Verssimo Ricardo Luiz Simes Houly Cria Vieira Barbosa Eliane Aparecida Campesatto and Maria Lysete de Assis Bastos

Keywords

Medicinal plants, Healing, Nursing., Hyptis pectinata extract

 
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