alexa Abstract | STUDY ON EFFICACY OF TREATMENT WITH FICUS BENGHALENSIS LEAF EXTRACTS ON FREUND’S ADJUVANT INDUCED ARTHRITIS IN RATS

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

In view of the well-established anti-inflammatory properties of bark and leaf of Ficus benghalensis, the present study was carried out to evaluate the protective effect of ethanol and aqueous leaf extracts against Freund?s adjuvant induced arthritis in rats. The ethanol and aqueous leaf extracts was administered orally at dose of 300 mg/kg body weight for 21 days. Indomethacin at dose of 10 mg/kg body weight was used as standard drug. The paw volume was measured on days 4, 8, 14, and 21. At the end of day 21 the blood was collected from retro-orbital route to all the groups of animals and various haematological parameters such as haemoglobin content, total WBC, RBC and erythrocyte sedimentation rate were estimated. The results indicate that at dose of 300 mg/kg body weight, both the extracts protects rats against the primary and secondary arthritic lesions, body weight changes and haematological perturbations induced by CFA. Daily treatment of rats with ethanol and aqueous leaf extracts, standard drug Indomethacin effectively inhibits paw edema in rats. Both the extracts significantly (p< 0.01) altered the parameters which were estimated when compared to control group rats. At the end of studies the ethanol extract shows more pronounce effect 66.88% than the aqueous extract 63.82% as compared to standard drug Indomethacin 75.42%. The phytochemical analysis of extracts revels the presence of sterols, flavonoids, phenols, tannins and saponins. However additional clinical investigations are needed to prove the efficacy of Ficus benghalensis L.in the treatment of various immuno-inflammatory disorders.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Lokesh K Bhardwaj Kalpana S Patil MKaushik Amit Sahu YPrakashVKVerma

Keywords

Freund’s adjuvant, arthritic, Ficus benghalensis, Moraceae, leaf.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords