alexa Abstract | Substrate Metabolism and Mitochondrial Function in Skeletal Muscle of Amyloid Precursor Protein-Overexpressing Mice

Annals of Clinical and Laboratory Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Background: Sporadic Inclusion body myositis (sIBM) is an idiopathic inflammatory myopathy that involves inflammation and damage to skeletal muscle tissue. Studies in humans demonstrate altered mitochondrial morphology in skeletal muscle from patients diagnosed with sIBM suggesting mitochondrial defects may be a significant contributor to disease progression.

Methods: MCK-APP mice, overexpress amyloid precursor protein specifically in skeletal muscle, display characteristics of sIBM, and are an accepted model to study disease pathology.

Results: The current studies demonstrate a significant reduction in fat oxidation and oxidative efficiency in white gastrocnemius muscle in 9-month-old MCKAPP. However, there were no differences in mitochondrial bioenergetics or the production of reactive oxygen species in red or white gastrocnemius muscle in 3, 6, or 9-month-old MCK-APP mice compared to wild-type littermates.

Conclusion: Functional alterations in mitochondria are not yet pronounced in 3, 6, and 9-month-old MCK-APP mice prior to symptom development; however alterations in substrate metabolism in white skeletal muscle may be present.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Elika Shabrokh John Kavanaugh Ryan McMillan Yaru Wu Matt Hulver and Madlyn Frisard

Keywords

Amyloid precursor protein, Amyloid beta, Bioenergetics, Fatty acid oxidation, Mitochondrial metabolism, Skeletal muscle metabolism, Reactive oxygen species, Clinical biochemistry, Investigational new drug, Clinical Trial

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords