alexa Abstract | Synchronous Triple Cancers of the Pancreas, Stomach, and Cecum Treated with S-1 Followed by Pancrelipase Treatment of Pancreatic Exocrine Insufficiency

JOP. Journal of the Pancreas
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Context Pancreatic cancer is frequently complicated by malignancies in other organs. However, synchronous triple cancersincluding pancreatic cancer have been seldom reported in the English language literature. Case report We describe the rare case of a 77-year-old man with triple cancers of the pancreas, stomach, and cecum. Biopsies revealed that all three tumors were adenocarcinomas. The pancreatic and gastric tumors were positive for cytokeratin 7 and negative for cytokeratin 20, whereas the cecal tumor was negative for cytokeratin 7 and positive for cytokeratin 20. K-ras mutations were present at codon 12 in the pancreatic tumor and at codon 13 in the cecal tumor, but were absent from the gastric tumor. Since the three tumors had different characteristics, the patient was diagnosed with synchronous triple cancers. Because invasive surgery was required to remove all three tumors and the patient had risk factors for surgery, we elected to treat him with chemotherapy. All three cancers were markedly reduced in size by treatment with cycles of 100 mg/day S-1 for 2 weeks,followed by a 1-week rest. The patient later developed hypoproteinemia and anasarca, which was diagnosed as pancreaticexocrine insufficiency due to pancreatic head cancer. Treatment with pancrelipase resulted in dramatic improvements inhypoproteinemia and anasarca. Conclusions This is the first case report in which S-1 was effective in triple cancers of thepancreas, stomach, and cecum. Patients with pancreatic head cancer should be monitored for pancreatic exocrineinsufficiency.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Hisatsugu Mouri Koushiro Ohtsubo Daisuke Ishikawa Shigeki Nanjo Shinji Takeuchi Tadaaki Yamada Kaname Yamashita Kazuo Yasumoto Toshifumi Gabata Osamu Matsui Hiroko Ikeda Yasushi Takamatsu Sakae Iwakami Seiji Yano

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version