alexa Abstract | Syntheses of some novel 5-Substituted-Arylidene-3-Substituted- Benzyl-Thiazolidine-2, 4-Dione Analogues as Anti-Hyperglycemic Agents

International Journal of Drug Development and Research
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Abstract

A series of 5-substituted-arylidene-3-substitutedbenzyl- thiazolidine-2, 4-dione derivatives were synthesized through Knoevenagel condensation and studied for their glucose lowering capability against alloxan induced diabetic rats. Some of the compounds showed appreciable antidiabetic activity comparable to standard drug rosiglitazone.

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Author(s): Garg Ankush Chawla Pooja Saraf A Shubhini

Keywords

Thiazolidine-2,4-dione, Heterocyclic compounds, PPAR, Antidiabetic activity

 
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