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Research Paper Open Access
Resorcinol on reaction with ethylacetoacetate in the presence of concentrated sulphuric acid afforded 7-hydroxy-4-methyl chromen-2-one (1), which when refluxed with 1-bromo-3-chloropropane in acetonitrile and in the presence of anhydrous potassium carbonate yielded 7-(3-chloropropoxyl)- 4-methyl chromen-2-one (2). Substitution of chlorine from (2) with secondary amines in toluene and in the presence of triethylamine resulted in the title compounds (3a-e) in 50-60 % yield. Their chemical structures have been assigned by elemental analysis , IR ,and 1HNMR analyses. The compounds were screened for 5-HT2A antagonist activity and spontaneous motor activity. All title compounds have been found to show significant 5-HT2A antagonist activity and caused reduction in spontaneous motor activity.
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Author(s): M V L Aparna N Sati V S Veer S H Bhosale M S Bhosale S L Bodhankar K R Mahadik S S Kadam