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Research Paper Open Access
A series of some novel compounds 2-(un) substituted-3-amino-5-aryl-6-phenylpyrazolo [3,4-d] pyrimidine-4 (5H)-ones were synthesized by condensation of 2-phenyl-3-aryl-5-cyano-6- thiomethyl pyrimidine-4(3H)-ones independently with hydrazine hydrate/methyl hydrazine/phenyl hydrazine in presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate. These derivatives were characterized by their spectral data. When evaluated for analgesic activity by hot plate method, compounds 4e, 4i, 4I and 4m exhibited superior activity than Pentozocin hydrochloride at dose of 10 mg/kg. The ED50 values of all thirteen synthesized compounds were determined.
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Author(s): I S Rathod K G Baheti V S Shirsath