alexa Abstract | Synthesis and antibacterial activity of Cu (II) complex of some novel 5-nitroimidazole derivatives

Journal of Chemical and Pharmaceutical Research
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The Cu (II) complex of novel 2-(1-substituted-5-nitro-1H-imidazol-2-yl)-1-substitutedethanone derivatives have been designed, synthesized and characterized by UV, IR, 1HNMR, Mass and conductivity measurements. 2- substituted 5-nitroimidazole acts as a bidentate ligand through the N-3 of imidazole ring and carbonyl group, which coordinate the copper ion to form 4-coordinate tetrahedral Cu (II) complex. Synthesized compounds then evaluated in-vitro for their antibacterial activity using cup plate method. Some of the metal complexes were found to be moderately active against Gram-positive bacteria, B. pumilus ATCC 14884 and S. aureus ATCC 29737.

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Author(s): D G Desai B R Prajapati A K Seth and D K Sureja


Copper (II) complex, 5-nitroimidazole, Antibacterial activity, Antibacterial activity

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