alexa Abstract | Synthesis and Antibacterial activity of some 4,5-disubstituted-6-Methyl-1,2,3,4- Tetrahydropyrimidin-2(1H)-one derivatives

International Journal of Drug Development and Research
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Abstract

Eight new 4,5-disubstituted-6-methyl-1,2,3,4- tetrahydropyrimidin-2(1H)-one derivatives are synthesized by three steps. All synthesized compounds are confirmed by IR, Mass and H1NMR. Antibacterial activity is carried out by filter disc method. All test compounds are active against the gram negative E.coli and in higher concentration active against the gram positive S.aureus. Compounds 6b and 6e are more potent among synthesized series.

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Author(s): Divyang H Shah and Dhrubo Jyoti Sen

Keywords

Biginelli reaction, Tetrahydropyrimidines, Zone of inhibition, Gram +ve bacteria, Gm –ve bacteria

 
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