alexa Abstract | Synthesis and antibacterial assessment of <i>N</i> -[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine

Indian Journal of Pharmaceutical Sciences
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Abstract

In a wide search program towards new and efficient antibacterial agents, we assessed the extent to which physicochemical properties can be exploited to promote antibacterial activity associated with a series of substituted s-triazine. The synthesized compounds (1a-12b) were subsequently screened for their in vitro antibacterial activity against three gram positive ( Bacillus subtilis, Bacillus cereus, Staphylococcus aureus ) and three Gram-negative microorganism ( Salmonella typhi, Escherichia coli, Klebsiella aerogenes ) by the broth dilution technique, recommended by European Committee for antimicrobial susceptibility testing with reference to streptomycin.

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Author(s): P Gahtori A Das H Bhatt

Keywords

Bacterial resistance, physicochemical properties, s-Triazine, broth dilution technique, antibacterial activity

 
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