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Original Articles Open Access
Series of seven 5-phenyl-1H-pyrazole-3-carboxylic acid amide derivatives were prepared by varying the active part (amide group) of pyrazole. All the synthesized compounds were characterized by, 1H NMR, 13C NMR and mass spectrometry and were screened, antifungal activity, against four fungal pathogens such as Candida albicans, Aspergillus flavus, Aspergillus fumigatus and Aspergillus niger using broth microdilution method. Active compounds were also screened for MIC (minimum inhibitory concentration) and MFC (minimum fungicidal concentrations). Two compounds 5b and 5f were found to be more potent than standard actidione drugs, against Candida albicans strains.
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Author(s): Amar Patil Rahul Jadhav Hemant Raundal Lokesh Sharma Rupali Badgujar and Vivek Bobade
Pyrazole carboxamide, antifungal activity, MIC and MFC, antifungal activities