alexa Abstract | Synthesis and antifungal activity of novel metal chelates based on 8-hydroxyquinoline and piperazine ring

Journal of Chemical and Pharmaceutical Research
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Abstract

1-(4-((8-hydroxyquinolin-5-yl)diazenyl)phenyl)-2-(4-ethylpiperazin-1-yl)ethanone (AEPEHQ) was synthesized by diazotization reaction of 8-hyroxyquinolinol (HQ) and 1-(4-aminophenyl)-2-(4-ethylpiperazin-1-yl)ethanone (AEPE), which was characterized by elemental analysis and spectral studies. The transition metal chelates Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) of AEPEHQ were prepared and characterized by metal-ligand (M:L) ratio, IR ,reflectance spectroscopies and magnetic properties. The antifungal activity of AEPEHQ and its metal chelates was screened against various fungi. The results show that all these samples show good antifungal agents.

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Author(s): Hitendra D Raj and Yogesh S Patel

Keywords

2-(4-ethyl piperazin-1-yl)-1-(4-((8-hydroxy quinolin-5-yl)diazenyl) phenyl)ethanone, 8-hyroxy quinolinol, Spectroscopies study, Magnetic moment and Antifungal properties., antifungal activity

 
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