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Original Articles Open Access
A series of thiophene appended substituted pyrimidin-2-one analogues were synthesized by an accessible approach. The reaction of chalcones 1(a-e) and urea 2 in the presence potassium hydroxide in ethanol yielded 6-aryl-4- (thiophen-2-yl)-5,6-dihydropyrimidin-2(1H)-ones, 3(a-e) in good yields. The synthesized new compounds were characterized by 1H NMR, 13C NMR, Mass spectral studies and elemental analysis and were screened for their antifungal susceptibility against different fungi species.
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Author(s): Shwetha G Hegde A Dileep Kumar and K Ajay Kumar
Antifungal, cyclocondensation, inhibition, pyrimidine, urea, antifungal activity