alexa Abstract | Synthesis and antihypertensive activity of 4'-{2-[4-[2-(Substitutedphenyl)- 4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-yl-methyl}- biphenyl-2-carboxylic acids

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Structures of all the synthesized compounds have been corroborated on the basis of elemental IR, 1H NMR, 13C NMR and Mass spectro-analytical data. Many Schiff bases were prepared by condensation reaction of compounds containing biphenyl carboxylic acid with aromatic aryl aldehydes derivatives with Thiazoldine-4-one. The synthesized compounds 4'-{2-[4-[2- (Substituted-phenyl)-4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-ylmethyl}-biphenyl-2- carboxylic acid react with mercaptoacetic acid and 4'-bromomethylbiphenyl-2-carboxylic acid and all synthesis compounds screened for Angiotension (A II) Receptor Antagonist antihypertensive activity with biphenyl carboxylic acid Schiff bases Thiazoldine-4-one shows good activity compared with losartan and Telmisartan.

To read the full article Peer-reviewed Article PDF image

Author(s): M C Sharma D V Kohli Smita Sharmab and A D Sharma

Keywords

Biphenyl carboxylic acid, Thiazoldine-4-one, Angitotensin II, antihypertensive drug, Losartan, Telmisartan

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords