alexa Abstract | Synthesis and antihypertensive activity of 4'-{2-[4-[2-(Substitutedphenyl)- 4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-yl-methyl}- biphenyl-2-carboxylic acids

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Structures of all the synthesized compounds have been corroborated on the basis of elemental IR, 1H NMR, 13C NMR and Mass spectro-analytical data. Many Schiff bases were prepared by condensation reaction of compounds containing biphenyl carboxylic acid with aromatic aryl aldehydes derivatives with Thiazoldine-4-one. The synthesized compounds 4'-{2-[4-[2- (Substituted-phenyl)-4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-ylmethyl}-biphenyl-2- carboxylic acid react with mercaptoacetic acid and 4'-bromomethylbiphenyl-2-carboxylic acid and all synthesis compounds screened for Angiotension (A II) Receptor Antagonist antihypertensive activity with biphenyl carboxylic acid Schiff bases Thiazoldine-4-one shows good activity compared with losartan and Telmisartan.

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Author(s): M C Sharma D V Kohli Smita Sharmab and A D Sharma


Biphenyl carboxylic acid, Thiazoldine-4-one, Angitotensin II, antihypertensive drug, Losartan, Telmisartan

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