alexa Abstract | Synthesis and antihypertensive activity of some new benzimidazole derivatives of 4'-(6-methoxy-2-substituted-benzimidazole-1-ylmethyl)- biphenyl-2-carboxylic acid in the presences of BF3·OEt2

Der Pharmacia Sinica
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Research Article Open Access

Abstract

A series of 4'-(6-Methoxy-2-substituted-benzimidazole-1-ylmethyl)-biphenyl-2-carboxylic acid were synthesized expeditiously in good yields from 4-methoxy-1, 2-phenylenediamine and different substituted carboxylic acids in the presence of BF3·OEt2 as a catalyst with biphenyl carboxylic acid have been confirmed by IR,1H NMR,MS and elemental analysis. The title compounds have been evaluated for antihypertensive activity direct and indirect methods. Some of these compounds have been found to exhibit excellent antihypertensive activity.

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Author(s): M C Sharma D V Kohli Smita Sharmab and A D Sharma

Keywords

BF3·OEt2, angiotensin II, biphenyl-2-carboxylic acid

 
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