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Research Paper Open Access
Mannich bases of N-acetyl-2-phenylindole were synthesized using different secondary amines. The formation of the products was confirmed by analytical and spectral data. Anti-inflammatory activities of the synthesized compounds were evaluated by carrageenan induced eodema of the rat paw method. All the compounds tested,showed fairly greater activity than the parent compound at a dose level of 100 mg/kg. Compound 3-(pyrrolidinomethyl)N-acetyl-2-phenyylindole showed greater activity in comparision to phenylbutazone.