alexa Abstract | Synthesis and antiinflammatory activity of n-aryl anthranilic acid and its derivatives

Indian Journal of Pharmaceutical Sciences
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Abstract

N-aryl anthranilic acid and its derivatives (3a-f) have been synthesized via Ullmann condensation of o-chloro benzoic acid with various substituted anilines (2a-f) in the presence of cupric oxide and anhydrous potassium carbonate. All the synthesized compounds (3a-f) were characterized by mp, TLC, UV, IR, 1 H NMR and mass spectral analysis. All the synthesized compounds (3a-f) were screened for their antiinflammatory activity by carrageenan induced rat paw edema method. All the synthesized compounds (3a-f) showed significant antiinflammatory activity. Compounds 3a and 3c were found to be the most potent compounds.

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Author(s): JK Joshi VR Patel K Patel D Rana K Shah Ronak Patel Rajesh Patel

 
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