alexa Abstract | Synthesis and antimicrobial activity of 5-imidazolinone derivatives

Indian Journal of Pharmaceutical Sciences
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Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of OH, OCH 3 , NO 2 , Cl and Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.

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Author(s): NC Desai AM Bhavsar BB Baldaniya


5-Imidazolinone, antibacterial activity, antifungal activity

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