alexa Abstract | Synthesis and antimicrobial activity of benzothiazine containing thiosemicarbazides and 1,3,4-thiadiazole derivatives

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access


A series of novel 3-methyl-7-substituted-4H-1,4-benzothiazine-2-carbohydrazide (3a-e) and corresponding thiosemicarbazides (4a-q); 2-[3-methyl-7-substituted-4H-1,4-benzothiazine-2-yl]-N-(aryl)hydrazine carbothiamide have been synthesized. By the intramolecular cyclization of thiosemicarbazide compounds 4a–q in concentrated H2SO4, thiadiazoles were obtained in high yields and the compounds were tested for antibacterial and antifungal activities against different microorganisms.

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Author(s): Bhikan J Khairnar Pravin S Girase and Bhata R Chaudhari


1,4-Benzothiazine, 1,3,4-Thiadiazole, Thiosemicarbazide, Intramolecular cyclisation, Antimicrobial activity., antimicrobial activity

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