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Research Paper Open Access
A series of novel 2-substituted-3-(sulphonamido) quinazolin-4 (3H)-ones have been synthesized by condensing the primary amino group of sulphamoxole and sulphadimidine with 2-substituted benzoxazin-2-one. The compounds synthesized were screened for antibacterial activity (Escherichia coli and Staphylococcus aureus) antiviral activity (Herpes simplex virus type 1 and 2 in E6SM cells, HIV-1 and 2 in MT-4 cells), all the test compounds exhibited comparable antibacterial activity with that of standards sulphamoxole and sulphadimidine.
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Author(s): P Selvam K Vanitha M Chandramohan E De Clercq