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Research Article Open Access
A novel series of benzimidazole analogues possessing substituted piperazine were synthesized for their antimicrobial activity. The structures of the compounds were elucidated using elemental analysis, IR, 1H-NMR and mass spectral data. The synthesized compounds were tested for their in vitro antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, the Gram negative bacteria Proteus mirabilis and Pseudomonas aeruginosa, the fungal strain Aspergillus niger and the yeast like pathogenic fungus Candida albicans, by disk diffusion method. Some of compounds displayed significant activities against all the pathogenic microorganisms tested including Pseudomonas aeruginosa and Candida albicans responsible for nosocomial infection. Structure activity relationship among the synthesized compounds was also studied.
benzimidazole, Piperazine, antimicrobial activity.