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Quinazolines are building blocks for approximately 150 naturally occurring alkaloids with a wide variety of biological responses. The substituents present on C-2 and N-3 of the quinazoline molecule plays in critical role in promoting several biological activities. Hence a new azaisatins derivative containing 4(3H) quinazolinones has been designed and synthesized. Their structures have been elucidated on the basis of elemental analysis and spectral studies. All the compounds synthesized were screened for their potential antimicrobial activities, which exhibited some authentic results towards testing organism invitro and invivo studies.
Quinazoline, azaisatins, antimicrobial.