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2,6,8-Trisubstituted-3-thiosemicarbazido-4(3H)-quinazolones(3)and (4), synthesized by the condensation of 3-amino-2,6,8-trisubstituted-4 (3H)-quinazolones (1 and 2) with carbon disulphide and hydrazine hydrate in presence of liquid ammonia, were reacted with arylaldehydes such as 4-dimethylaminobenzaldehyde, 2-furaldehyde and 2-naphthaldehyde to afford corresponding thiosemicarbazones (5-10). All these compounds were characterized by their analytical and spectral data. Some of them were found to possess moderate antibacterial and antifungal properties on evaluation.
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Author(s): G V S Rama Sarma J Harish B Suresh