alexa Abstract | Synthesis and antimicrobial studies of fused heterocycles ‘pyrimidobenzothiazoles’

Journal of Chemical and Pharmaceutical Research
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Abstract

In the present work 2H-Pyrimido[2,1-b]benzothiazole-2-ones were synthesized by reacting 2-aminobenzothiazoles with alkynoic acid in butanol and 4H-Pyrimido[2,1-b]benzothiazole-4-ones were synthesized by the reaction of 2- aminobenzothiazoles with ethylacetoacetate in presence of polyphosphoric acid. The structures of synthesized compound were confirmed by IR, H1NMR & mass spectrum analysis. Synthesized compounds shown biological activity against E. coli and B. Subtilis and anti-fungal activity against A. fumigates.

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Author(s): Gulshan Kumar Praveen Kumar Sharma Silky Sharma and Simranjeet Singh

Keywords

2-aminobenzothiazoles, 2-methyl-4H-pyrimido[2,1-b]benzothiazol-4-ones, 4-methyl-2H-pyrimido[2,1-b]benzothiazol-2-ones, alkynoic acid, antimicrobial studies

 
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