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Original Articles Open Access
A number of 8-anilino-6-aryl-3,4-dihydrophenanthridine-1,7,10(2H)-triones were synthesized to measure their halfwave potentials and assessed for their in vitro antiproliferative activity on a panel of a non-tumor fibroblast and four human-derived tumor cell lines, using the MTT assay. The SAR analysis indicates that the antiproliferative activity is strongly dependent on the electron-donor and inductive effects of methoxy and bromine substituents, inserted into the 8-anilino-6-arylphenanthridinequinone scaffold. Among the series, three members showed significant antiproliferative activity (0.58-5.78 μM).
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Author(s): Juana A Ibacache Jaime A Valderrama Cristina Theoduloz Julio Benites and Giulio Mucciolli
phenanthridinequinones, halogenation, half-wave potential, cancer cells, antiproliferative activity, 8-anilino-6-arylphenanthridinequinones