alexa Abstract | Synthesis and antiulcer activity studies of 2-(1'-iminothioimido substituted)-1'-substituted phenylbenzoic acids

Indian Journal of Pharmaceutical Sciences
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Certain 2-(1'-iminothioimido substituted)-1'-substituted phenybenzoic acids (P 1-9 ) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A 1-3 ) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl-3-methyl-5-pyrazolone. Antiulcer activity was evaluated using reduction in total acidity, free acidity and ulcer index as parameters. Compounds P 3 , P 6 , P 7 and P 9 (100 mg/kg) showed significant (P<0.001) antiulcer action compared to control and omeprazole (40 mg/kg).

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Author(s): BB Subudhi D Bhatta PK Panda P Mishra D Pradhan


Benzothiazole, benzotriazole, benzimidazole, total acidity, free acidity, ulcer index

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