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The condensation of 5-chloro-3-methyl-2-benzofuran carbohydrazide (4) with phenylisothiocynate gave 5-chloro-3-methylbenzofuran-2-carbo-N-phenylthiosemicarbazide (5). The cyclisation of 5 under different reaction conditions furnished 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,4-triazole, thiadiazolidinone and thiopyrimidone. Their chemical structures have been assigned by IR,1HNMR, Mass and elemental analyses. All the compounds synthesized were evaluated for antibacterial and antifungal activity.
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Author(s): S S Sangapure Raga Basawaraj