alexa Abstract | Synthesis and biological activity of 1,2,3-triazoyl chalcones

Journal of Chemical and Pharmaceutical Research
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Abstract

Chalcones, with a chemical formula of trans-1,3-diaryl-2-propen-1-one, belong to flavonoids group. These are naturally synthesised by many plant species. As the extraction procedure from the natural sources is quite expensive and complicated, many researchers have proposed many synthetic procedures for this purpose. These compounds are of scientific interest because of the many useful properties it shows like anticancer, antimicrobial, antioxidant activities, etc. These chalcones in nature are present as intermediates in plant metabolic processes. These can also be used as precursor for the synthesis of heterocyclic compounds. These heterocyclic compounds obtained from chalcones further show many beneficial characteristics in medical field. 1, 2, 3-triazoyl chalcones, Compounds A3ad are synthesized and their structure has been evaluated using 1H-Nmr and IR, Their biological activity studies anti cancer and antibacterial studies have been carried out, In Gram Positive bacteria compound A3b and compound A3c were showing more Anti Bacterial activity at 150ug concentration, In Gram Negative bacteria compound A3b and compound A3c were showing more Anti Bacterial activity at 150ug concentration. The gel electrophoresis experiment does not show any apparent cleavage in the presence of H2O2 when compared with Control DNA. The compounds were treated with Breast cancer cell lines and MTT assay was done but the compounds did not show any anti cancer activity it was confirmed with standard Cisplatin.

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Author(s): Ahmed Habeeb Radhi and Y Hemasri

Keywords

Chalcones, flavonoids, Anti-bacterial activity, Anti-Cancer activity, DNA Cleavage Studies., 1,2,3-triazoyl chalcones

 
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