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Some oxo and thioxotetrahydropyrimidines 4(a-j) were prepared using multicomponent reaction of ?-keeto ester, arylaldehyde and urea/thiourea in the presence of the NaY zeolite. The microbiological activity of these compounds was tested in vitro against Escherichia Coli (PTCC 1338), Pseudomonas aeruginosa (PTCC 1074), Entrococcus faecalis (PTCC 1237) and Staphylococcus aureus (PTCC 1119) bacteria.
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Author(s): Akbar Mobinikhaledi and Mehdi Kalhor
Pyrimidine, catalyst, zeolite, biological activity, carboxylate