alexa Abstract | Synthesis and biological activity studies of some thiazolidinones and azetidinones

Indian Journal of Pharmaceutical Sciences
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Abstract

A series of 4-thiazolidinones and 2-azetidinones have been synthesized by condensation of 4,4'-diaminodiphenylsulphone with various aromatic or heterocyclic aldehydes to yield the Schiff's bases. Cyclocondensation of Schiff's bases with 2-mercaptopropionic acid afforded 4-thiazolidinone derivatives, and cyclocondensation of Schiff's bases with chloroacetylchloride in presence of triethylamine afforded 2-azetidinone derivatives. The structures of the newly synthesized compounds were confirmed by analytical and spectral (IR, NMR, and Mass) data. All these compounds were evaluated for their in vitro growth-inhibitory activity against several microbes. Compound 4b and 4c exhibited equipotent antibacterial activity with the reference standard ampicillin against Bacillus subtilis.

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Author(s): PD Mehta N PS Sengar E VS Subrahmanyam D Satyanarayana

 
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