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Quinazoline ring is an aromatic benzopyrimidine system; many of its derivatives possess interesting biological activities, such as analgesic, anti-inflammatory, anti-microbial, and anti-tumor. In our study, the biological activity of synthesized novel 5-(2’-hydroxy phenyl)- 6,7,8,9 tetra hydro-5H-(1, 3) thiazolo-2-(4?-substituted benzylidine) (2, 3- b) quinazolin-3-phenyl hydrazone were characterized by antimicrobial screening against several gram-positive, gram negative bacteria, and fungus. The purity of the synthesized compounds was characterized by means of IR, 1HNMR, mass spectral and elemental analysis. Antimicrobial screening for all the compounds exhibits characteristic microbial inhibition against Bacillus lentus, Micrococcus luteus, Bacillus cereus, Staphylococcus albus, Escherichia coli, Klebsiella aerogenes, Salmonella paratyphi, Proteus vulgaris and Candida albicans.
Quinazolin-3(2H)-one, Quinazolin-3-phenyl hydrazone, Anti-bacterial, Anti-fungal.