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4,6-Diaryl substituted-4,5-dihydro-2-amino pyrimidines have been synthesized by the reaction of chalcones with guanidine nitrate. Their chemical structures have been confirmed by means of IR and NMR data and by elemental analysis. The compounds were screened for antibacterial activity against 16 gram-positive bacterial strains in minimum inhibitory concentration. The minimum inhibitory concentration of the compound II has found to be better than the reference standards taken for the antibacterial screening. Sulphamethoxazole and trimethoprim were taken as reference standards.