alexa Abstract | Synthesis and Biological Evaluation of Novel Cholesterol Lowering Agents

Asian Journal of Biomedical and Pharmaceutical Sciences
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Propitious hypolipidemic activity has been reported in droves of 2- substitutedthieno(2,3-d)pyrimidines. Earlier 2-(chloromethyl)-5,6,7,8-tetrahydro(1) benzothieno(2,3-d)pyrimidin-4(3H)-one (I, LM-1554, CAS89567-03-3) have been extensively evaluated pharmacologically and toxicologically for hypolipidemic activities. Its 4-chloro analog (II) recently revealed much supercilious activity to it. Scientific exploration and clinical studies have already archieved the importance of Niacin (Vitamin B3) in reducing blood cholesterol levels and other consequential risk factors in the blood. Further, it also documented to contribute in the repair of artery wall. With this rationalization, the synthesis & biological evaluation of novel mutual prodrugs composing the LM 1554 nucleus and vitamin B3 molecule was ventured through the consecutive synthetic routes.

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Author(s): Bhagwat Chavan Aniruddha R Chabukswar Anuja Kalidas Kolsure Ketan Gulabrao Albhar Jayadeep Ramesh Yadav Kisan Raghunath Bobe


LM-1554, Vitamin B3, Prodrugs, Hypolipidemic activity

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