alexa Abstract | Synthesis and Biological Evaluation of Some Novel Coumarin and Guanidine Derivatives by Oral Glucose Tolerance Test

American Journal of Advanced Drug Delivery
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Objective: The major drawback of current treatment of diabetes is challenging due to resistance to antidiabetic agents their side effects. Chromenes occurs naturally in plants and plays role of anticoagulant activity. Guanidine plays role of antidiabetic activity. 2H-chromenes are the heterocyclic compounds with considerable therapeutic and pharmacological properties. Guanidine is compounds with considerable therapeutic and pharmacological properties. In this view, it has been planned to combine both guanidine and coumarin derivatives. Biological activity for antidiabetic activity has been performed for guanidine derivatives.

Experimental and Computational work done: 2H-chromene was synthesized by Pechmann condensation of resorcinol, ethyl acetoacetate and sulphuric acid. Then coumarin was combined with guanidine. This combined compound was substituted by different substituted benzaldehyde and in other series by oxidation, chlorination and Schotten Baumann reaction. The purity of the compounds was checked by TLC monitoring and all the synthesized compounds were characterized by UV, IR, Mass and some of by 1H-NMR spectroscopy. The antidiabetic activities of synthesized compounds were tested by oral glucose tolerance test (OGTT).

Results and discussion: In antidiabetic activity, compounds 9-b have shown highest antidiabetic activity while compounds 9-a and 11-a have shown also antidiabetic activity against metformin as standard.

Conclusion: Evaluation of antidiabetic revealed that compounds with substituted benzaldehyde at the 4-position of the phenyl ring of 2H-chromenes and at oxidation, chlorination and Schotten Baumann reaction of synthesized intermediate i.e., 9-a is most active antidiabetic agent.

To read the full article Peer-reviewed Article PDF image

Author(s): Vahan G Prajapati and Dr Dhrubo Jyoti Sen

Keywords

2H-chromene, antidiabetic activity, oral glucose tolerance test (OGTT)

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords