alexa Abstract | Synthesis and biological evaluation of some substituted benzoxazole derivatives as antibacterial agents

Der Pharmacia Sinica
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Research Article Open Access

Abstract

Synthesis of benzoxazoles by treating 4-ethylsulphonyl-2-aminophenols or 4-Methyl-2-aminophenols with substituted benzoic acid derivatives is reported in this piece of research to establish new candidates with improved antimicrobial property. These reactions are operationally simple and proceed in average yield. Compounds are biologically evaluated against gram positive and gram negative bacteria S. aureus and E. coli. The synthesized compounds possessed a broad spectrum of activity with zone of inhibition in concentration 10-80 μg/ml. The range for percentage relative inhibition is observed to be 32.1% to 45.5 % in S. aureus, the range for percentage relative inhibition is observed to be 40 % to 51.8 % in E. coli.

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Author(s): Anupama Parate Love Kumar Soni and Richa Malviya

Keywords

Benzoxazole, synthesis, antimicrobial agents

 
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