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Research Article Open Access
2-(5-((Naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) aceto hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-arylene-2-(5-((naphthalen-1- yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride yields N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-2-(5- ((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamide (3a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
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Author(s): Ashok PrasadK S Nimavat and K B Vyas
2-(5-((Naphthalen-1-yloxy) methyl)-2-thioxo-1, 3, 4-oxa diazol-3(2H)-yl) aceto hydrazide, azetidinone, antibacterial activity, spectral studies