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Original Articles Open Access
Hydroxypropyl cellulose (HPC) was modified to contain chloroacetate groups by the reaction of HPC with chloroacetyl chloride in dried dichloromethane by using pyridine as a catalyst. The coupling of para-aminobenzoic acid (PABA) to HPC functionalized with chloroacetate groups was carried out in a homogenous reaction between chloroacetylated HPC and sodium salt of PABA in dimethylsulfoxide (DMSO). The structures of chloroacetylated HPC and HPC-PABA conjugates were well characterized by FT-IR and 1H-NMR techniques. The degree of substitution (DS) per anhydroglucose unit (AUG) of chloroacetylated HPC and HPC-PABA ester conjugate was calculated by using integrated area from1H-NMR spectra. Synthesis and structural characterizations of HPC-PABA ester conjugate was successfully carried out and this strategy will contribute to the development of a potential macromolecular carrier for biomedical and pharmaceutical applications.
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Author(s): KashifurRehman Khan and Chitchamai Ovatlarnporn
p-Aminobenzoic acid, Esterification, Hydroxypropyl cellulose,1H-NMR , FT-IR