alexa Abstract | Synthesis and characterization of ornidazole, 5-ASA azo adduct for colon targetting

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The main objective of our research work is to prepare Ornidazole azo adduct with 5-ASA for colon targeting . We synthesized Ornidazole 5-ASA azo adduct and examine the effect of enzyme azo reductase on the release rate of ornidazole and 5-ASA in the gastrointestinal contents of rats. By using this approach two drugs can be targeted at the same time in the colon so as to treat the various disease of colon such as Crohn’s disease and ulcerative colitis. The azo adduct did not release drug in acidic environment of stomach, but when the azo adduct drugs will enter into colon the enzyme azo reductase break the azo bond and releases the dual drugs. By using this approach two drugs can be released at same time in colon .The azo adduct was evaluated for its color, solubility, Rf value, melting point and IR spectral analysis. It was further subjected for evaluating its colon targeting property by in-vitro method using rat fecal matter.

To read the full article Peer-reviewed Article PDF image

Author(s): Rajeev Kumar Sharma N V Satheesh Madhav and A K Sharma

Keywords

Ulcerative Coltis, Crohn’s disease, Azo adduct, Azoreductase, 5-ASA, colon targetting

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords