alexa Abstract | Synthesis And CNS Depressant Of Newer Spirobarbiturates

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


In an effort to search for more active CNS depressants, a series of spirobarbiturates incorporated with thiazolidinones and azetidinones were synthesized and evaluated for their sedative, hypnotic and anticonvulsant activities. Starting bis compounds (1a-d) were prepared from the reaction of acetone and substituted aldehydes. These bis compounds on Michael addition with barbituric acid give rises to triones (2a-d), which on condensation with NH2NH2.H2O afforded (3a-d) which on reaction with different aromatic aldehydes afforded and Schiff bases (4a-n). These on cyclocondensation with thiolactic acid and chloroacetyl chloride furnished the final products (5a-n) and (6a-n), respectively. Result of toxicity studies and central nervous system depressant activities of these compounds are reported. The structures of the products have been delineated by chemical reaction, elemental analysis and spectral studies.

To read the full article Peer-reviewed Article PDF image

Author(s): B Goel S Sharma K Bajaj D Bansal T Singh N Malik S Lata C Tyagi H Panwar A Agarwal A Kumar

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version