alexa Abstract | Synthesis and cytotoxic activity of tanshinone I derivatives having azacyclo moiety

Journal of Chemical and Pharmaceutical Research
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Abstract

Three-component coupling of 3-amino-1,2,4-triazole, aldehydes and 3-hydroxy-8- methyl-1,4-phenanthrenequinone has been achieved using a catalytic amount of p-TsOH under solvent-free conditions to produce a novel series of tanshinone I derivatives having azacyclo in good yields and with high regioselectivity. These compounds are found to exhibit potent antitumoral properties.

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Author(s): Liqiang Wu and Xiaojuan Yang

Keywords

cytotoxic

 
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