alexa Abstract | Synthesis and evaluating cardiac effects of 3,4-dihydropyrimidin-2-one-5-carboxylates in isolated atria of animal model

Journal of Chemical and Pharmaceutical Research
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Abstract

The synthesis and cardiac activity of four 3,4-dihydropyrimidin-2-one-5 carboxylates are reported. We synthesized 3,4-Dihydropyrimidinones (DHPMs) by Biginelli reaction using classic and microwave methods and the yield of these methods compared with each other. Then cardiotonic activity of four derivatives of DHPMs was investigated on isolated perfused right atria. Compound 2b had significant chronotropic effect in comparison to negative control at concentration of 0.01M.

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Author(s): Moein Rashidifar Mohsen Imenshahidi Neda RahmaniFazli and Farzin Hadizadeh

Keywords

Dihydropyrimidines, Synthesis, Biginelli Compounds, Isolated Atria, Synthesis and evaluating cardiac

 
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