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Research Paper Open Access
Seven new 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(2-methyl phenyl) carbamoyl-1, 4-dihydropyridines were prepared through one-pot synthesis starting from (2-methylphenyl) acetoacetamide using appropriate aromatic aldehydes and liquid ammonia. These compounds were purified and characterized by their analytical and spectral data. Pharmacological screening of the new 1,4-dihydropyridines was carried out for CNS depresant (anticonvulsant and analgesic) and cardiovascular (inotropic and blood pressure) activities by standard methods. Quite a few of them were found to be active.
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Author(s): S K Swamy T M Reddy V M Reddy