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Research Paper Open Access
The 2-arylsubstituted benzothiazole derivatives were synthesized by refluxing o-aminothiophenol with substituted benzoic acids in the presence of polyphosphoric acid at 220°. 2-Mercaptothiazole was used along with thionyl chloride to get the carbothioates. The physical and spectral data such as mp, Rf, IR, NMR was obtained for the synthesized compounds and the structures were confirmed. The screening for antitumour activity was done as per the National Cancer Institute drug screening strategy 3 compounds were found to be significantly cytotoxic as compared to [2-(3-bromo-4-aminophenyl) benzothiazole] against the human cervical cancer cell lines.