alexa Abstract | Synthesis And Evaluation Of Some Novel 2-(Substituted Amino) Benzimidazoles as H1-Receptor Blockers

Indian Journal of Pharmaceutical Sciences
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A variety of novel 2-(substitute amino) benzimidazoles have been synthesized by the cyclocondensation of o-phenylenediamine with a variety of dithiocarbamic esters. The title compounds were tested for their H1 - antihistaminic activity on isolated guinea pig ileum. While all the test compounds exhibited antihistaminic activity, the compound IVa was found to be more potent than the standard pheniramine maleate.

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Author(s): V Alagarasamy A Thangathiruppathy C Bothiraja P Saravanakumar G Sathyabalan S Rajkumar

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