alexa Abstract | Synthesis and in vitro antitubercular activity of 7-substituted fluoroquinolones

Indian Journal of Pharmaceutical Sciences
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Abstract

Three novel fluoroquinolones with general structure 1-t-butyl-7-[4-substituted (piperazin-1-yl/piperidin-1-yl)]-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acids were synthesized and evaluated for antitubercular activity in vitro against M. tuberculosis H37Rv in Middlebrook 7H9 broth using sparfloxacin, ciprofloxacin and isoniazid as standards. Test compounds were found to be less potent than sparfloxacin; however, one of the compounds was more potent than ciprofloxacin.

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Author(s): AV Shindikar CL Viswanathan

 
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